P-HYDROXYMETHAMPHETAMINE
Synonym(s):Pholderin
- CAS NO.：370-14-9
- Empirical Formula: C10H15NO
- Molecular Weight: 165.23
- MDL number: MFCD00178702
- EINECS: 206-725-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:33
What is P-HYDROXYMETHAMPHETAMINE?
Chemical properties
Off-White Solid
Originator
Pholedrine Sulfate, ZYF Pharm Chemical
The Uses of P-HYDROXYMETHAMPHETAMINE
An a-adrenergic agonist. Antihypotensive.
Definition
ChEBI: Pholedrine is a member of amphetamines.
Manufacturing Process
100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
Therapeutic Function
Sympathomimetic, Mydriatic, Analeptic, Vasopressor
Properties of P-HYDROXYMETHAMPHETAMINE
| Melting point: | 162-163° |
| Boiling point: | 293.09°C (rough estimate) |
| Density | 1.0203 (rough estimate) |
| refractive index | 1.4820 (estimate) |
| storage temp. | −20°C |
| solubility | Methanol (Slightly) |
| pka | 9.82±0.15(Predicted) |
| form | neat |
Safety information for P-HYDROXYMETHAMPHETAMINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for P-HYDROXYMETHAMPHETAMINE
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