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HomeProduct name listOxyfedrine

Oxyfedrine

Oxyfedrine Structural

What is Oxyfedrine?

Originator

Ildamen,Homburg,W. Germany ,1966

The Uses of Oxyfedrine

Oxyfedrine acts as a vasodilator affecting the coronary base flow.

Definition

ChEBI: Oxyfedrine is an aromatic ketone.

Manufacturing Process

45 grams of m-methoxy acetophenone, 8 grams of paraformaldehyde and 30.2 grams of 1 norephedrine were mixed with about 135 cc of isopropanol HCl solution to provide a pH of 4 and the mixture refluxed for 4 hours. The reaction mixture was cooled and the crystals filtered off on a suction filter. 3[1-phenyl-1-hydroxypropyl-(2)-amino]-1-(m-methoxyphenyl)-propanone-(1) HCl was obtained which after recrystallization from methanol had a MP of 190° to 193°C.

Therapeutic Function

Coronary vasodilator

Properties of Oxyfedrine

Melting point: 107-109°C
Boiling point: 475.2±28.0 °C(Predicted)
Density  1.122±0.06 g/cm3(Predicted)
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly), Methanol (Slightly), Toluene (Slightly)
pka 13.90±0.20(Predicted)
form  Solid
color  White to Off-White
Stability: Hygroscopic, Moisture Sensitive

Safety information for Oxyfedrine

Computed Descriptors for Oxyfedrine

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