OTS964

CAS NO.：1338545-07-5
Empirical Formula: C23H24N2O2S
Molecular Weight: 392.51386
MDL number: MFCD28386220
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-17 16:00:36

What is OTS964?

Description

OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC₅₀ = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.

The Uses of OTS964

OTS 964 works through cytokinesis and is an effective TOPK inhibitor which has been shown to cause tumor suppression in xenografts of human cancer.

References

1. matsuo y, park jh2, miyamoto t, et al. topk inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. ci transl med. 2014 oct 22;6(259):259ra145.

Properties of OTS964

storage temp.	Store at -20°C
solubility	≥88.6 mg/mL in DMSO; ≥2.15 mg/mL in EtOH with gentle warming and ultrasonic; ≥2.1 mg/mL in H2O with gentle warming and ultrasonic
form	crystalline solid
color	Off-white to light yellow

Safety information for OTS964

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.