ORG 24598 LITHIUM SALT
Synonym(s):R-(−)-N-Methyl-N-[3-[(4-trifluoromethyl)phenoxy]-3-phenyl-propyl]glycine lithium salt
- CAS NO.:722456-08-8
- Empirical Formula: C19H21F3LiNO3
- Molecular Weight: 375.32
- MDL number: MFCD08705419
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:09
What is ORG 24598 LITHIUM SALT?
The Uses of ORG 24598 LITHIUM SALT
Org 24598 Lithium Salt is a selective glycine transporter-1 (GlyT-1) inhibitor.
Biochem/physiol Actions
Org 24598 is a selective, potent inhibitor of glial GlyT (GlyT1, glycine transporter type 1). In rats (P12-P16) and in the presence of kynurenic acid, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, ORG 24598 at a concentration of 10 μM induced a mean inward current of -10/-50 pA at -60 mV and increased significantly the decay time constants of miniature (mIPSCs), spontaneous (sIPSCs) and electrically evoked glycinergic (eIPSCs) inhibitory postsynaptic currents. Replacing extracellular sodium with N-methyl-d-glucamine or superfusing the slice with micromolar concentrations of glycine also increased the decay time constant of glycinergic IPSCs. Glycine (1-5 μM and d-serine (10 μM) increased the amplitude of eEPSCs whereas l-serine had no effect. Org 24598 increased significantly the amplitude of NMDA receptor-mediated eEPSCs without affecting the amplitude of non-NMDA receptor-mediated eEPSCs. This brings conclusion that blocking glial glycine transporter by Org 24598 increased the level of glycine in spinal cord slices, which in turn prolonged the duration of glycinergic synaptic current and potentiated the NMDA-mediated synaptic response.
Properties of ORG 24598 LITHIUM SALT
storage temp. | 2-8°C |
solubility | H2O: >2mg/mL |
form | solid |
color | white to off-white |
Safety information for ORG 24598 LITHIUM SALT
Computed Descriptors for ORG 24598 LITHIUM SALT
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