n-Octyl-β-D-glucopyranoside
Synonym(s):n-Octyl glucoside;Octyl β-D -glucopyranoside;octyl glucoside; OG; OGP;Octyl-β-D -glucopyranoside solution;OGP
- CAS NO.:29836-26-8
- Empirical Formula: C14H28O6
- Molecular Weight: 292.37
- MDL number: MFCD00063288
- EINECS: 249-887-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-11 14:08:43
What is n-Octyl-β-D-glucopyranoside?
Description
n-Octyl-β-D-glucopyranoside is a non–ionic detergent intended for solubilizing membrane–bound proteins in their native state and for the preparation of lipid vesicles. n-Octyl-β-D-glucopyranoside has a well–defined chemical structure, small uniform micelles, and high water solubility, which make n-Octyl-β-D-glucopyranoside superior to most other nonionic detergents for membrane solubilization. Because of the high critical micelle concentration (20-25 mM), n-Octyl-β-D-glucopyranoside has the additional advantage of being removed easily by dialysis when compared to bile salts. n-Octyl-β-D-glucopyranoside is also known as N-Octyl glucoside, OGP, OG, n-Octylglucoside, and octyl-β-D-glucopyranoside.
Chemical properties
white crystalline powder and chunks
The Uses of n-Octyl-β-D-glucopyranoside
A nonionic detergent for the solubilization of membrane bound protein.
The Uses of n-Octyl-β-D-glucopyranoside
Unlike many other detergents, octyl glucoside is a pure, single compound of defined structure. Very effective for insulin binding and solubilization studies of membran
The Uses of n-Octyl-β-D-glucopyranoside
Detergent and surfactant for biological systems.
What are the applications of Application
n-Octyl-β-D-glucopyranoside is a mild, non-denaturing nonionic detergent that is used for the solubilization and reconstitution of membrane-bound proteins.
What are the applications of Application
n-Octylglucoside is a mild, non-denaturing detergent for the solubilization and reconstitution of membrane-bound proteins
Definition
ChEBI: Octyl beta-D-glucopyranoside is an beta-D-glucoside in which the anomeric hydrogen of beta-D-glucopyranose is substituted by an octyl group. It has a role as a plant metabolite.
Purification Methods
Purify n-Octyl-β-D-glucopyranoside by recrystallisation from Me2CO. It is hygroscopic and should be stored in a well-stoppered container. [Noller & Rockwell J Am Chem Soc 6 0 2076 1938, Pigman & Richtmyer J Am Chem Soc 64 369 1942.] It is a UV transparent non-ionic dialysable detergent for solubilising membrane proteins. The D-isomer with [] D 20 +118o (c 1, MeOH) has similar solubilising properties. [Lazo & Quinn Anal Biochem 102 68 1980, Stubbs et al. Biochim Biophys Acta 426 46 1976, Beilstein 17/7 V 38.]
Properties of n-Octyl-β-D-glucopyranoside
Melting point: | 105 °C |
Boiling point: | 354.3°C (rough estimate) |
alpha | -32 º (c=5, water) |
Density | 1.0869 (rough estimate) |
refractive index | -27 ° (C=1, MeOH) |
storage temp. | -20°C |
solubility | DMSO (Slightly), Water (Slightly) |
pka | 12.95±0.70(Predicted) |
form | Crystalline Powder and Chunks |
color | White |
Water Solubility | 3 g/10 mL |
Sensitive | Hygroscopic |
Merck | 14,6767 |
BRN | 84118 |
Stability: | Hygroscopic |
CAS DataBase Reference | 29836-26-8(CAS DataBase Reference) |
EPA Substance Registry System | Octyl .beta.-D-glucopyranoside (29836-26-8) |
Safety information for n-Octyl-β-D-glucopyranoside
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for n-Octyl-β-D-glucopyranoside
InChIKey | HEGSGKPQLMEBJL-QNOVJUQQSA-N |
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