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HomeProduct name listn-Octyl-β-D-glucopyranoside

n-Octyl-β-D-glucopyranoside

Synonym(s):n-Octyl glucoside;Octyl β-D-glucopyranoside;octyl glucoside; OG; OGP;Octyl-β-D-glucopyranoside solution;OGP

  • CAS NO.:29836-26-8
  • Empirical Formula: C14H28O6
  • Molecular Weight: 292.37
  • MDL number: MFCD00063288
  • EINECS: 249-887-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-11 14:08:43
n-Octyl-β-D-glucopyranoside Structural

What is n-Octyl-β-D-glucopyranoside?

Description

n-Octyl-β-D-glucopyranoside is a non–ionic detergent intended for solubilizing membrane–bound proteins in their native state and for the preparation of lipid vesicles. n-Octyl-β-D-glucopyranoside has a well–defined chemical structure, small uniform micelles, and high water solubility, which make n-Octyl-β-D-glucopyranoside superior to most other nonionic detergents for membrane solubilization. Because of the high critical micelle concentration (20-25 mM), n-Octyl-β-D-glucopyranoside has the additional advantage of being removed easily by dialysis when compared to bile salts. n-Octyl-β-D-glucopyranoside is also known as N-Octyl glucoside, OGP, OG, n-Octylglucoside, and octyl-β-D-glucopyranoside.

Chemical properties

white crystalline powder and chunks

The Uses of n-Octyl-β-D-glucopyranoside

A nonionic detergent for the solubilization of membrane bound protein.

The Uses of n-Octyl-β-D-glucopyranoside

Unlike many other detergents, octyl glucoside is a pure, single compound of defined structure. Very effective for insulin binding and solubilization studies of membran

The Uses of n-Octyl-β-D-glucopyranoside

Detergent and surfactant for biological systems.

What are the applications of Application

n-Octyl-β-D-glucopyranoside is a mild, non-denaturing nonionic detergent that is used for the solubilization and reconstitution of membrane-bound proteins.

What are the applications of Application

n-Octylglucoside is a mild, non-denaturing detergent for the solubilization and reconstitution of membrane-bound proteins

Definition

ChEBI: Octyl beta-D-glucopyranoside is an beta-D-glucoside in which the anomeric hydrogen of beta-D-glucopyranose is substituted by an octyl group. It has a role as a plant metabolite.

Purification Methods

Purify n-Octyl-β-D-glucopyranoside by recrystallisation from Me2CO. It is hygroscopic and should be stored in a well-stoppered container. [Noller & Rockwell J Am Chem Soc 6 0 2076 1938, Pigman & Richtmyer J Am Chem Soc 64 369 1942.] It is a UV transparent non-ionic dialysable detergent for solubilising membrane proteins. The D-isomer with [] D 20 +118o (c 1, MeOH) has similar solubilising properties. [Lazo & Quinn Anal Biochem 102 68 1980, Stubbs et al. Biochim Biophys Acta 426 46 1976, Beilstein 17/7 V 38.]

Properties of n-Octyl-β-D-glucopyranoside

Melting point: 105 °C
Boiling point: 354.3°C (rough estimate)
alpha  -32 º (c=5, water)
Density  1.0869 (rough estimate)
refractive index  -27 ° (C=1, MeOH)
storage temp.  -20°C
solubility  DMSO (Slightly), Water (Slightly)
pka 12.95±0.70(Predicted)
form  Crystalline Powder and Chunks
color  White
Water Solubility  3 g/10 mL
Sensitive  Hygroscopic
Merck  14,6767
BRN  84118
Stability: Hygroscopic
CAS DataBase Reference 29836-26-8(CAS DataBase Reference)
EPA Substance Registry System Octyl .beta.-D-glucopyranoside (29836-26-8)

Safety information for n-Octyl-β-D-glucopyranoside

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for n-Octyl-β-D-glucopyranoside

InChIKey HEGSGKPQLMEBJL-QNOVJUQQSA-N

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