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HomeProduct name listOCHRATOXIN B

OCHRATOXIN B

  • CAS NO.:4825-86-9
  • Empirical Formula: C20H19NO6
  • Molecular Weight: 369.37
  • MDL number: MFCD00133680
  • EINECS: 621-766-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:07:02
OCHRATOXIN B Structural

What is OCHRATOXIN B?

Description

Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods. Ochratoxin A (OTA, ) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas. OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 μg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.

The Uses of OCHRATOXIN B

Ochratoxin B is the non-chlorinated analogue of the much more extensively studied ochratoxin A. It is co-produced by the same species of Aspergillus and Penicillium that are associated with food spoilage. Ochratoxin B has received little focused investigation and its mode of action and potential hazards have been inferred from ochratoxin A.

The Uses of OCHRATOXIN B

Ochratoxins are toxic metabolites from Aspergillus orchraceus.

What are the applications of Application

Ochratoxin B is the non-chlorinated and less potent analog of Ochratoxin A

Definition

ChEBI: Ochratoxin B is a phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. Ochratoxin B differs from the more naturally abundant ochratoxin A in the absence of the dihydroisocoumarin chlorine atom. It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. It inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 mug/ ml but lacks the genotoxic activity of ochratoxin A, even at higher concentrations. It has a role as an Aspergillus metabolite, a Penicillium metabolite, a mycotoxin and a calcium channel blocker. It is a phenylalanine derivative, a N-acyl-L-phenylalanine, a member of isochromanes and a monocarboxylic acid. It is a conjugate acid of an ochratoxin B(1-).

General Description

Crystals that exhibit blue fluorescence.

Reactivity Profile

OCHRATOXIN B is incompatible with strong oxidizing agents, strong acids and strong bases. OCHRATOXIN B is a carboxylic acid derivative. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt.

Fire Hazard

Flash point data for OCHRATOXIN B are not available. OCHRATOXIN B is probably combustible.

Properties of OCHRATOXIN B

Melting point: 221° (van der Merwe)
Boiling point: 632.4±55.0 °C(Predicted)
alpha  D -35° (c = 0.15 in ethanol)
Density  1.361±0.06 g/cm3(Predicted)
Flash point: -11 °C
storage temp.  2-8°C
solubility  DMF: 10 mg/ml; DMSO: 15 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.50 mg/ml
form  A crystalline solid
pka 3.40±0.10(Predicted)
color  White to off-white
EPA Substance Registry System L-Phenylalanine, N-[[(3R)-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]- (4825-86-9)

Safety information for OCHRATOXIN B

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for OCHRATOXIN B

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