O-ACETYLSALICYLOYL CHLORIDE
- CAS NO.:5538-51-2
- Empirical Formula: C9H7ClO3
- Molecular Weight: 198.6
- MDL number: MFCD00000663
- EINECS: 226-899-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-19 17:35:41
What is O-ACETYLSALICYLOYL CHLORIDE?
Chemical properties
yellow to light orange chunks
The Uses of O-ACETYLSALICYLOYL CHLORIDE
O-Acetylsalicyloyl chloride was used in the synthesis of enantiomerically pure bidentate heteroorganic ligands built on simple achiral skeletons and containing an aziridine moiety. It was used in the general synthesis of acetoxybenzamides. It was used in the chemical synthesis of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)-aspirin conjugate via condensation reaction with 4-hydroxy-TEMPO. It was used as reagent in acylation of cyclobutenediones.
Purification Methods
Check first the IR to see if an OH frequency is present. If so, some free acid is present. Then reflux with acetyl chloride for 2-3hours and fractionate at high vacuum. The distillate should crystallise. It can be recrystallised from hexane or *C6H6 (m 60o, sintering at 52o). [Riegel & Wittcoff J Am Chem Soc 64 486 1942, Beilstein 10 H 86, 10 I 43, 10 II 55, 10 III 151, 10 IV 169.]
Properties of O-ACETYLSALICYLOYL CHLORIDE
Melting point: | 45-49 °C (lit.) |
Boiling point: | 107-110 °C/0.1 mmHg (lit.) |
Density | 1.3219 (rough estimate) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | powder to lump |
color | White to Orange to Green |
Water Solubility | Soluble in toluene. Reacts with water. |
Sensitive | Moisture Sensitive |
BRN | 880372 |
Stability: | Moisture Sensitive |
CAS DataBase Reference | 5538-51-2(CAS DataBase Reference) |
NIST Chemistry Reference | Acetylsalicyloyl chloride(5538-51-2) |
Safety information for O-ACETYLSALICYLOYL CHLORIDE
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for O-ACETYLSALICYLOYL CHLORIDE
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