Fmoc-N-amido-PEG24-acid

CAS NO.：850312-72-0
Empirical Formula: C66H113NO28
Molecular Weight: 1368.59332
MDL number: MFCD08705351
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-26 15:56:31

What is Fmoc-N-amido-PEG24-acid?

Description

Fmoc-N-amido-PEG24-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

The Uses of Fmoc-N-amido-PEG24-acid

O-(N-Fmoc-2-aminoethyl)-O''-(2-carboxyethyl)undecaethyleneglycol is used as a linker in the preparation of PEG-peptide surfaces as attractive platforms for the development of peptide microarrays.

What are the applications of Application

Some applications of O-[2-(Fmoc-amino)-ethyl]-O'-(2-carboxyethyl)polyethylene glycol 3000 (Fmoc-N-amido-PEG36-acid) include the development of flexible antibodies with non-protein hinges, the development of optimized liposomes for intracellular protein delivery, and the development of conjugates for SPECT imaging of cancer in vivo.

Properties of Fmoc-N-amido-PEG24-acid

storage temp.

2-8°C

Safety information for Fmoc-N-amido-PEG24-acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Fmoc-N-amido-PEG24-acid

InChIKey	YYQNCNHFUALMKW-UHFFFAOYSA-N
SMILES	C(O)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(C1C2=C(C=CC=C2)C2=C1C=CC=C2)C(OC)=O