Fmoc-N-amido-PEG24-acid
- CAS NO.：850312-72-0
- Empirical Formula: C66H113NO28
- Molecular Weight: 1368.59332
- MDL number: MFCD08705351
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-26 15:56:31
What is Fmoc-N-amido-PEG24-acid?
Description
Fmoc-N-amido-PEG24-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
The Uses of Fmoc-N-amido-PEG24-acid
O-(N-Fmoc-2-aminoethyl)-O''-(2-carboxyethyl)undecaethyleneglycol is used as a linker in the preparation of PEG-peptide surfaces as attractive platforms for the development of peptide microarrays.
What are the applications of Application
Some applications of O-[2-(Fmoc-amino)-ethyl]-O'-(2-carboxyethyl)polyethylene glycol 3000 (Fmoc-N-amido-PEG36-acid) include the development of flexible antibodies with non-protein hinges, the development of optimized liposomes for intracellular protein delivery, and the development of conjugates for SPECT imaging of cancer in vivo.
Properties of Fmoc-N-amido-PEG24-acid
| storage temp. | 2-8°C |
Safety information for Fmoc-N-amido-PEG24-acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Fmoc-N-amido-PEG24-acid
| InChIKey | YYQNCNHFUALMKW-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(C1C2=C(C=CC=C2)C2=C1C=CC=C2)C(OC)=O |
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![O-[2-(Boc-amino)ethyl]-Oμ-(2-carboxyethyl)polyethylene glycol 3,000](https://img.chemicalbook.in/CAS/20180714/GIF/187848-68-6.gif)
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