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HomeProduct name listNucleoside phosphorylase

Nucleoside phosphorylase

Synonym(s):Nucleoside Phosphorylase bacterial;PNP;Purine nucleoside phosphorylase;Purine nucleoside:orthophosphate ribosyltransferase

  • CAS NO.:9030-21-1
  • Empirical Formula: C10H12N4O4
  • Molecular Weight: 252.22668
  • MDL number: MFCD00131739
  • EINECS: 232-857-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:37
Nucleoside phosphorylase Structural

What is Nucleoside phosphorylase?

Chemical properties

Powder

The Uses of Nucleoside phosphorylase

Nucleoside Phosphorylase from microorganisms has been used:

  • in phosphopentomutase assay for adenosine synthesis
  • for the conversion of 7-methylthioguanosine to 7-methylthioguanine
  • in the synthesis of cytokinins in lyophilized cotton plant samples

General Description

Nucleoside Phosphorylase are trimeric and have a molecular mass of about 100 kDa. Each monomer consists of a mixed β-sheet core flanked by eight α-helices and a purine binding in hydrophobic pocket.

Biochem/physiol Actions

Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Mutations in the PNP gene are responsible for purine nucleoside phosphorylase deficiency.

Properties of Nucleoside phosphorylase

storage temp.  -20°C
form  lyophilized powder
color  White to off-white
InChI InChI=1/C10H12N4O4/c15-2-6-7(16)8(17)10(18-6)14-4-13-5-1-11-3-12-9(5)14/h1,3-4,6-8,10,15-17H,2H2/t6-,7-,8-,10-/s3

Safety information for Nucleoside phosphorylase

Computed Descriptors for Nucleoside phosphorylase

InChIKey MRWXACSTFXYYMV-DOGWMMLDNA-N
SMILES O1[C@@H](N2C3=C(N=C2)C=NC=N3)[C@H](O)[C@H](O)[C@H]1CO |&1:1,11,13,15,r|

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