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HomeProduct name listNSC 361680

NSC 361680

NSC 361680 Structural

What is NSC 361680?

Description

Bis-PEG1-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

The Uses of NSC 361680

Bis-PEG1-acid is a PEG-based PROTAC linker and can be used in the synthesis of PROTACs as BCL-xL degraders and anticancer agents with low platelet toxicity.

Properties of NSC 361680

Melting point: 60-61 °C
Boiling point: 198-200 °C(Press: 1-2 Torr)
Density  1.316±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer, Under inert atmosphere
solubility  Aqueous Base (Slightly), Chloroform (Slightly), Methanol (Slightly), Water (Slig
form  Solid
pka 3.96±0.10(Predicted)
color  Pale Yellow to Light Yellow

Safety information for NSC 361680

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for NSC 361680

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