NSC 361680
- CAS NO.：5961-83-1
- Empirical Formula: C6H10O5
- Molecular Weight: 162.14
- MDL number: MFCD06208032
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is NSC 361680?
Description
Bis-PEG1-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
The Uses of NSC 361680
Bis-PEG1-acid is a PEG-based PROTAC linker and can be used in the synthesis of PROTACs as BCL-xL degraders and anticancer agents with low platelet toxicity.
Properties of NSC 361680
| Melting point: | 60-61 °C |
| Boiling point: | 198-200 °C(Press: 1-2 Torr) |
| Density | 1.316±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Aqueous Base (Slightly), Chloroform (Slightly), Methanol (Slightly), Water (Slig |
| form | Solid |
| pka | 3.96±0.10(Predicted) |
| color | Pale Yellow to Light Yellow |
Safety information for NSC 361680
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NSC 361680
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