NSC 150117 hydrochloride
Synonym(s):(E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one; 2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride;NSC 150117 hydrochloride
- CAS NO.：95130-23-7
- Empirical Formula: C22H24ClNO
- Molecular Weight: 353.885
- MDL number: MFCD16875416
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is NSC 150117 hydrochloride?
The Uses of NSC 150117 hydrochloride
(E/Z)-BCI hydrochloride has been used:
- to evaluate the role of the Duox-H2O2-Dusp6 derepression signaling pathway in heart regeneration
- as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects
- as a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells
Biochem/physiol Actions
BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.
Properties of NSC 150117 hydrochloride
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
Safety information for NSC 150117 hydrochloride
Computed Descriptors for NSC 150117 hydrochloride
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