noxytiolin
- CAS NO.:15599-39-0
- Empirical Formula: C3H8N2OS
- Molecular Weight: 120.17
- MDL number: MFCD00866765
- EINECS: 2396795
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:34
What is noxytiolin?
Originator
Noxyflex,Geistlich,UK,1964
Background
Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for burns.
Definition
ChEBI: Noxytiolin is a member of thioureas.
Manufacturing Process
400 g methyl thiourea and 2.5 g NaHCO3 are dissolved in 400 ml formaldehyde solution of 35% concentration. After having been left at ordinary temperature for 2 to 3 hours, the solution is adjusted with dilute HCl to pH 7 to 7.5. After the reaction mixture had been left overnight at 15°C some of the final product crystallized and was filtered off using a Buchner funnel. The mother liquor was concentrated by evaporation in vacuo at a bath-temperature of 30°C. The crystals obtained were again collected by filtration using a Buchner funnel and were combined with the first crystalline fraction and dried in vacuo at ordinary temperature. Yield of pure substance 400 g; melting point 84°C to 86°C.
Therapeutic Function
Antifungal
Metabolism
Not Available
Properties of noxytiolin
Melting point: | 88-90° |
Boiling point: | 203.7±42.0 °C(Predicted) |
Density | 1.223±0.06 g/cm3(Predicted) |
pka | 13.45±0.10(Predicted) |
Safety information for noxytiolin
Computed Descriptors for noxytiolin
New Products
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