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HomeProduct name listNOVOBIOCIN SODIUM SALT

NOVOBIOCIN SODIUM SALT

Synonym(s):Salmonella Selective Supplement;Modified Semi-solid RAPPAPORT-VASSILIADIS Selective Supplement;MSRV Selective;Novobiocin sodium salt;Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem

  • CAS NO.:1476-53-5
  • Empirical Formula: C31H37N2NaO11
  • Molecular Weight: 636.63
  • MDL number: MFCD30207859
  • EINECS: 216-023-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
NOVOBIOCIN SODIUM SALT Structural

What is NOVOBIOCIN SODIUM SALT?

Chemical properties

crystalline

The Uses of NOVOBIOCIN SODIUM SALT

Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.

The Uses of NOVOBIOCIN SODIUM SALT

antibacterial

The Uses of NOVOBIOCIN SODIUM SALT

Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.

What are the applications of Application

Novobiocin Sodium Salt is an Hsp90 and DNA gyrase inhibitor

brand name

Albamycin (Pharmacia & Upjohn).

Clinical Use

The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.

Purification Methods

The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]

Properties of NOVOBIOCIN SODIUM SALT

Melting point: 215-220 C
alpha  D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  H2O: soluble50mg/mL
form  White to yellow solid
color  white to faintly beige
PH 7.5 (100g/l, H2O, 25℃)
optical activity [α]20/D 48±3°, c = 1% in ethanol
Water Solubility  Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol.
Merck  13,6755
BRN  3892910
Stability: Hygroscopic

Safety information for NOVOBIOCIN SODIUM SALT

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for NOVOBIOCIN SODIUM SALT

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