NOVOBIOCIN SODIUM SALT
Synonym(s):Salmonella Selective Supplement;Modified Semi-solid RAPPAPORT-VASSILIADIS Selective Supplement;MSRV Selective;Novobiocin sodium salt;Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem
- CAS NO.:1476-53-5
- Empirical Formula: C31H37N2NaO11
- Molecular Weight: 636.63
- MDL number: MFCD30207859
- EINECS: 216-023-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 21:39:59
What is NOVOBIOCIN SODIUM SALT?
Chemical properties
crystalline
The Uses of NOVOBIOCIN SODIUM SALT
Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.
The Uses of NOVOBIOCIN SODIUM SALT
antibacterial
The Uses of NOVOBIOCIN SODIUM SALT
Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.
What are the applications of Application
Novobiocin Sodium Salt is an Hsp90 and DNA gyrase inhibitor
brand name
Albamycin (Pharmacia & Upjohn).
Clinical Use
The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.
Purification Methods
The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]
Properties of NOVOBIOCIN SODIUM SALT
Melting point: | 215-220 C |
alpha | D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | H2O: soluble50mg/mL |
form | White to yellow solid |
color | white to faintly beige |
PH | 7.5 (100g/l, H2O, 25℃) |
optical activity | [α]20/D 48±3°, c = 1% in ethanol |
Water Solubility | Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol. |
Merck | 13,6755 |
BRN | 3892910 |
Stability: | Hygroscopic |
Safety information for NOVOBIOCIN SODIUM SALT
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NOVOBIOCIN SODIUM SALT
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
You may like
-
Novobiocin sodium salt 95% CAS 1476-53-5View Details
1476-53-5 -
MSRV Selective Supplement CAS 1476-53-5View Details
1476-53-5 -
Dechloro DesloratadineView Details
-
Dehydro DesloratadineView Details
-
Edoxaban Impurity 57View Details
2089454-69-1 -
Empagliflozin Bromo ImpurityView Details
-
Glycopyrronium Bromide EP Impurity IView Details
1404617-94-2 -
Ipratropium EP Impurity BView Details
58073-59-9