N,N-dimethylarginine
- CAS NO.:30315-93-6
- Empirical Formula: C8H18N4O2
- Molecular Weight: 202.25
- MDL number: MFCD00038406
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-25 20:04:51
What is N,N-dimethylarginine?
The Uses of N,N-dimethylarginine
Metabolomics
Definition
ChEBI: A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group.
General Description
Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and then into blood plasma.
Properties of N,N-dimethylarginine
Boiling point: | 340.8±52.0 °C(Predicted) |
Density | 1.23±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C(protect from light) |
solubility | DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): freely soluble |
form | A crystalline solid |
pka | 2.50±0.24(Predicted) |
color | White to off-white |
Safety information for N,N-dimethylarginine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N,N-dimethylarginine
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