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HomeProduct name listN,N-dimethylarginine

N,N-dimethylarginine

N,N-dimethylarginine Structural

What is N,N-dimethylarginine?

The Uses of N,N-dimethylarginine

Metabolomics

Definition

ChEBI: A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group.

General Description

Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and then into blood plasma.

Properties of N,N-dimethylarginine

Boiling point: 340.8±52.0 °C(Predicted)
Density  1.23±0.1 g/cm3(Predicted)
storage temp.  2-8°C(protect from light)
solubility  DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): freely soluble
form  A crystalline solid
pka 2.50±0.24(Predicted)
color  White to off-white

Safety information for N,N-dimethylarginine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for N,N-dimethylarginine

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