N,N-DIETHYLNICOTINAMIDE

Description

A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]_D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.

Chemical properties

clear colorless to yellow liquid

The Uses of N,N-DIETHYLNICOTINAMIDE

analeptic

The Uses of N,N-DIETHYLNICOTINAMIDE

N,N-Diethylnicotinamide (DENC) is commonly used as a ligand to prepare tetranuclear copper complexes.

Definition

ChEBI: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

What are the applications of Application

N,N-Diethylnicotinamide (DENA) is one of the central respiratory stimulants and is used in the study of respiratory failure. DENA is also an excellent hydrophilic agent for paclitaxel (PTX) and improves the water solubility of PTX.

General Description

Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.

Air & Water Reactions

Water soluble.

Reactivity Profile

N,N-DIETHYLNICOTINAMIDE is incompatible with sodium carbonate solutions which cause precipitation. .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N-DIETHYLNICOTINAMIDE emits toxic fumes.

Fire Hazard

N,N-DIETHYLNICOTINAMIDE is combustible.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.

References

Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971)