NDI-010976
- CAS NO.:1434635-54-7
- Empirical Formula: C28H31N3O8S
- Molecular Weight: 569.63
- MDL number: MFCD28963986
- Update Date: 2024-07-02 08:55:16
What is NDI-010976?
Description
ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.
The Uses of NDI-010976
Firsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.
Properties of NDI-010976
Boiling point: | 779.0±70.0 °C(Predicted) |
Density | 1.42±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM) Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM) |
form | A crystalline solid |
pka | 3.66±0.10(Predicted) |
color | White to light yellow |
Safety information for NDI-010976
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NDI-010976
New Products
6-Bromo 2-Iodo Indole Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin I Tubulysin H Tubulysin A (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell Methyl 4-amino-3-(dihexylamino)benzoate Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 1-(4-Fluorophenyl)piperidin-2-one 3,3,6,6-Tetramethylcyclohexane-1,2-dione 4-(Azidomethyl)-3-chloropyridine 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 5-bromo-3-iodopyridin-2-ol (2S,4R)-4-((tert-butoxycarbonyl)amino)-5-(4-hydroxyphenyl)-2-methylpentanoic acid 4-bromopyrimidin-2-amine 3-bromo-5-fluorobenzaldehydeRelated products of tetrahydrofuran
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