napyradiomycin A1
- CAS NO.：103106-24-7
- Empirical Formula: C25H30Cl2O5
- Molecular Weight: 481.413
- MDL number: MFCD01712236
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is napyradiomycin A1?
Description
Napyradiomycin A1 is a fungal metabolite originally isolated from C. rubra and has diverse biological activities. It is active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 μg/ml). Napyradiomycin A1 is an estrogen receptor antagonist (IC50 = 4.2 μM in rat uterine homogenates). It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM, respectively).
The Uses of napyradiomycin A1
Napyradiomycin derivatives have antibacterial and tumor properties. Napyradiomycin A1 is a secondary metabolite isolated from Streptomyces. It is also an antibacterial antibiotic and an inhibitor of mitochondrial complexes I and II.
Definition
ChEBI: Napyradiomycin A1 is a member of menaquinones.
Properties of napyradiomycin A1
| Boiling point: | 642.5±55.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| form | A solid |
| pka | 6.14±0.70(Predicted) |
Safety information for napyradiomycin A1
Computed Descriptors for napyradiomycin A1
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