Naloxone hydrochloride dihydrate

Synonym(s):Naloxone hydrochloride dihydrate

CAS NO.：51481-60-8
Empirical Formula: C19H26ClNO6
Molecular Weight: 399.87
MDL number: MFCD00150901
EINECS: 610-669-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

Naloxone hydrochloride dihydrate Structural

What is Naloxone hydrochloride dihydrate?

Chemical properties

White or almost white, hygroscopic, crystalline powder.

The Uses of Naloxone hydrochloride dihydrate

Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.

The Uses of Naloxone hydrochloride dihydrate

Antagonist (to narcotics).

brand name

Narcan (Bristol-Myers Squibb); Narcan (Endo).

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Purification Methods

This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]

Properties of Naloxone hydrochloride dihydrate

Melting point:	182 °C (dec.)(lit.)
storage temp.	2-8°C
solubility	ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
form	powder
color	white to off-white
optical activity	[α]25/D 178.6°, c = 2.5 in H2O(lit.)
Merck	13,6388
BRN	6260807
CAS DataBase Reference	51481-60-8(CAS DataBase Reference)

Safety information for Naloxone hydrochloride dihydrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.