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HomeProduct name listNaloxone hydrochloride dihydrate

Naloxone hydrochloride dihydrate

Synonym(s):Naloxone hydrochloride dihydrate

  • CAS NO.:51481-60-8
  • Empirical Formula: C19H26ClNO6
  • Molecular Weight: 399.87
  • MDL number: MFCD00150901
  • EINECS: 610-669-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Naloxone hydrochloride dihydrate Structural

What is Naloxone hydrochloride dihydrate?

Chemical properties

White or almost white, hygroscopic, crystalline powder.

The Uses of Naloxone hydrochloride dihydrate

Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.

The Uses of Naloxone hydrochloride dihydrate

Antagonist (to narcotics).

brand name

Narcan (Bristol-Myers Squibb); Narcan (Endo).

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Purification Methods

This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]

Properties of Naloxone hydrochloride dihydrate

Melting point: 182 °C (dec.)(lit.)
storage temp.  2-8°C
solubility  ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
form  powder
color  white to off-white
optical activity [α]25/D 178.6°, c = 2.5 in H2O(lit.)
Merck  13,6388
BRN  6260807
CAS DataBase Reference 51481-60-8(CAS DataBase Reference)

Safety information for Naloxone hydrochloride dihydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Naloxone hydrochloride dihydrate

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