Naloxone hydrochloride dihydrate
Synonym(s):Naloxone hydrochloride dihydrate
- CAS NO.:51481-60-8
- Empirical Formula: C19H26ClNO6
- Molecular Weight: 399.87
- MDL number: MFCD00150901
- EINECS: 610-669-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is Naloxone hydrochloride dihydrate?
Chemical properties
White or almost white, hygroscopic, crystalline powder.
The Uses of Naloxone hydrochloride dihydrate
Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.
The Uses of Naloxone hydrochloride dihydrate
Antagonist (to narcotics).
brand name
Narcan (Bristol-Myers Squibb); Narcan (Endo).
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.
Purification Methods
This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]
Properties of Naloxone hydrochloride dihydrate
Melting point: | 182 °C (dec.)(lit.) |
storage temp. | 2-8°C |
solubility | ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light. |
form | powder |
color | white to off-white |
optical activity | [α]25/D 178.6°, c = 2.5 in H2O(lit.) |
Merck | 13,6388 |
BRN | 6260807 |
CAS DataBase Reference | 51481-60-8(CAS DataBase Reference) |
Safety information for Naloxone hydrochloride dihydrate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Naloxone hydrochloride dihydrate
Abamectin manufacturer
Ralington Pharma
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