DMT-2′O-MOE-rMeC(bz) Phosphoramidite

CAS NO.：163759-94-2
Empirical Formula: C50H60N5O10P
Molecular Weight: 922.01
MDL number: MFCD00792624
Update Date: 2024-10-28 16:48:35

What is DMT-2′O-MOE-rMeC(bz) Phosphoramidite?

The Uses of DMT-2′O-MOE-rMeC(bz) Phosphoramidite

N4-Benzoyl-5''-O-DMT-2''-O-methylcytidine 3''-CE phosphoramidite (CAS# 163759-94-2) is a nucleotide used in the stereoselective synthesis of nucleoside alkyl-phosphonates.

General Description

DMT-2′O-MOE-rMeC(bz) Phosphoramidite (N4-Bz-5'-O-DMTr-2'-O-(2-methoxyethyl)-5-methylcytidine-3'-CED-phosphoramidite) is a phosphoramidite that belongs to the family of amides of trivalent phosphorus acid H3PO3. N4-Bz-5'-O-DMTr-2'-O-(2-methoxyethyl)-5-methylcytidine-3'-CED-phosphoramidite features a 2'-O-MOE group and can be incorporated into oligonucleotide phosphoramidites for antisense RNA. The 2'-MOE backbone enhances duplex stability, nuclease resistance, and has low toxicity.

Properties of DMT-2′O-MOE-rMeC(bz) Phosphoramidite

storage temp.	Store at -20°C
pka	8.59±0.40(Predicted)
form	Powder
color	White to Off-white

Safety information for DMT-2′O-MOE-rMeC(bz) Phosphoramidite

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…

Computed Descriptors for DMT-2′O-MOE-rMeC(bz) Phosphoramidite

InChIKey	FLIGVMLIIDVDSN-SQULMOJWNA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(NC(=O)C3=CC=CC=C3)=NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N \|&1:25,27,45,51,r\|