N-PHENYL-7-(HYDROXYIMINO)CYCLOPROPA[B]CHROMEN-1A-CARBOXAMIDE

CAS NO.：1161205-27-1
Empirical Formula: C17H14N2O3
Molecular Weight: 294.3
MDL number: MFCD00947860
SAFETY DATA SHEET (SDS)
Update Date: 2022-12-21 16:56:50

What is N-PHENYL-7-(HYDROXYIMINO)CYCLOPROPA[B]CHROMEN-1A-CARBOXAMIDE?

What are the applications of Application

PHCCC is a group I metabotropic glutamate receptor antagonist

Biological Activity

Group I metabotropic glutamate receptor antagonist (IC 50 ~ 3 μ M); 67 times more potent than (S)-4-carboxyphenylglycine ((S)-4-Carboxyphenylglycine). Also a positive allosteric modulator for mGlu 4a ; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro . Displays antiParkinsonian effects in rats in vivo .

Properties of N-PHENYL-7-(HYDROXYIMINO)CYCLOPROPA[B]CHROMEN-1A-CARBOXAMIDE

Boiling point:	579.1±50.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Store at RT
pka	10.79±0.40(Predicted)

Safety information for N-PHENYL-7-(HYDROXYIMINO)CYCLOPROPA[B]CHROMEN-1A-CARBOXAMIDE

Computed Descriptors for N-PHENYL-7-(HYDROXYIMINO)CYCLOPROPA[B]CHROMEN-1A-CARBOXAMIDE

New Products

(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION XANTHAN GUM Racecadotril SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Folic Acid Impurity G Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-Oxide