N-METHYLSUCCINIMIDE
- CAS NO.：1121-07-9
- Empirical Formula: C5H7NO2
- Molecular Weight: 113.11
- MDL number: MFCD00005517
- EINECS: 628-414-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:34
What is N-METHYLSUCCINIMIDE?
Chemical properties
white crystals
The Uses of N-METHYLSUCCINIMIDE
N-Methylsuccinimide is used as a model compound to investigate the mechanism of enolization step by density-functional theory (DFT) calculations. N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in plasma and urine can be used as a biomarker of exposure to NMP
What are the applications of Application
N-Methylsuccinimide is a model compound to investigate the mechanism of enolization step by density-functional theory (DFT) calculations
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 31, p. 4209, 1983 DOI: 10.1248/cpb.31.4209
General Description
N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in in plasma and urine can be used as a biomarker of exposure to NMP. Hydrogen bonded complexes between N-methylsuccinimide and phenols (pKa = 10.2 → 6) are investigated by infrared spectrometry.
Properties of N-METHYLSUCCINIMIDE
| Melting point: | 61-70 °C(lit.) |
| Boiling point: | 234-235 °C(lit.) |
| Density | 1.2416 (rough estimate) |
| refractive index | 1.4790 (estimate) |
| Flash point: | 234-235°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -1.34±0.20(Predicted) |
| color | Off-White |
| Sensitive | Moisture Sensitive |
| BRN | 110534 |
| CAS DataBase Reference | 1121-07-9(CAS DataBase Reference) |
Safety information for N-METHYLSUCCINIMIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-METHYLSUCCINIMIDE
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