N-Methylbenzene-1,2-diamine

CAS NO.：4760-34-3
Empirical Formula: C7H10N2
Molecular Weight: 122.17
MDL number: MFCD00192314
EINECS: 225-297-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 13:37:16

What is N-Methylbenzene-1,2-diamine?

The Uses of N-Methylbenzene-1,2-diamine

N-Methyl-1,2-phenylenediamine may be used in the following studies:

One-pot synthesis of 1-methyl-2(hetero)arylbenzimidazoles.
Preparation of 1-methyl-1H-benzimidazole-2(3H)-thione.
Total synthesis of the angiotensin II receptor antagonist, telmisartan.
Preparation of benzimidazoles from ketene dithioacetals.

What are the applications of Application

N-Methyl-1,2-phenylenediamine is a reagent used in the preparation of benzimidazoles

Synthesis Reference(s)

Synthetic Communications, 19, p. 1381, 1989 DOI: 10.1080/00397918908054547

General Description

N-Methyl-1,2-phenylenediamine is an ortho-diamine. In situ generated diazonium cations of N-methyl-1,2-phenylenediamine were used for the electrochemical modification of glassy carbon electrode.

Properties of N-Methylbenzene-1,2-diamine

Melting point:	22 °C (lit.)
Boiling point:	123-124 °C/10 mmHg (lit.)
Density	1.075 g/mL at 25 °C (lit.)
refractive index	n20/D 1.612(lit.)
Flash point:	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	Liquid
pka	6.17±0.10(Predicted)
color	Clear yellow to red to dark brown
CAS DataBase Reference	4760-34-3(CAS DataBase Reference)
EPA Substance Registry System	1,2-Benzenediamine, N-methyl- (4760-34-3)

Safety information for N-Methylbenzene-1,2-diamine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.