N-Methyl-1H-Indole-5-EthaneSulphonamide

CAS NO.：98623-50-8
Empirical Formula: C11H14N2O2S
Molecular Weight: 238.31
EINECS: 1592732-453-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-16 09:41:38

What is N-Methyl-1H-Indole-5-EthaneSulphonamide?

The Uses of N-Methyl-1H-Indole-5-EthaneSulphonamide

N-Methyl-1H-indole-5-ethanesulfonamide is used as a reagent in the synthesis of Naratriptan Hydrochloride (N378730); a triptan drug used for the treatment of migraine headaches.

General Description

N-Methyl-1H-Indole-5-EthaneSulphonamide, also known as 2-(1H-Indol-5-yl)-N-methylethanesulfonamide, is a white solid.

Synthesis

At 40-45 ℃ (hydrogen pressure: 3-4 kg/cm2), 2-(3-Phenylsulf-anyl-1H-indol-5-yl)-ethanesulfonic acidmethylamide (14) (5 g, 0.014 mol) was hydrogenated in ethanol: water (7:3) (40 ml) in an autoclave for 10 h. After that, the reaction mass was cooled to room temperature, followed by removing the catalyst through filtering. The filtrate was distilled out to get N-Methyl-1H-Indole-5-EthaneSulphonamide.

Properties of N-Methyl-1H-Indole-5-EthaneSulphonamide

Melting point:	124-125°C
Boiling point:	458.4±47.0 °C(Predicted)
Density	1.316±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	11.52±0.40(Predicted)
color	White to Off-White

Safety information for N-Methyl-1H-Indole-5-EthaneSulphonamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.