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HomeProduct name listN-Cbz-L-Leucine

N-Cbz-L-Leucine

Synonym(s):N-(Benzyloxycarbonyl)leucine;N-(Benzyloxycarbonyl)-L-leucine;N-(Carbobenzoxy)leucine;N-(Phenylmethoxy)carbonyl-L-leucine;N-Carbobenzoxy-L-leucine

  • CAS NO.:2018-66-8
  • Empirical Formula: C14H19NO4
  • Molecular Weight: 265.3
  • MDL number: MFCD00026494
  • EINECS: 217-960-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-22 18:19:53
N-Cbz-L-Leucine Structural

What is N-Cbz-L-Leucine?

Chemical properties

yellow oil or weak solid

The Uses of N-Cbz-L-Leucine

Reactant for:

  • Peptide-based preparation of potential antitumor agents
  • Preparation of cyclopropyl peptidomimetics
  • Peptide synthesis

Definition

ChEBI: A L-leucine derivative obtained by the substitution of a benzyloxycarbonyl group on the nitrogen atom.

Properties of N-Cbz-L-Leucine

Boiling point: 408.52°C (rough estimate)
alpha  -17 º (c=2, ethanol)
Density  1 g/mL at 25 °C(lit.)
refractive index  n20/D 1.512(lit.)
Flash point: 85 °F
storage temp.  Sealed in dry,2-8°C
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  viscous liquid
pka 4.00±0.21(Predicted)
Specific Gravity 1.0
color  Colorless to Light yellow
optical activity [α]20/D 17°, c = 2 in ethanol
Water Solubility  Not miscible or difficult to mix in water. Soluble in chloroform, DMSO and methanol.
BRN  1253861
CAS DataBase Reference 2018-66-8(CAS DataBase Reference)

Safety information for N-Cbz-L-Leucine

Signal word Warning
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Health Hazard
GHS08
GHS Hazard Statements H226:Flammable liquids
H351:Carcinogenicity
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378:In case of fire: Use … for extinction.

Computed Descriptors for N-Cbz-L-Leucine

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