Dmt-2'fluoro-da(bz) amidite
- CAS NO.:136834-22-5
- Empirical Formula: C47H51FN7O7P
- Molecular Weight: 875.92
- MDL number: MFCD12912392
- Update Date: 2024-11-17 16:00:36
What is Dmt-2'fluoro-da(bz) amidite?
Chemical properties
White to Light yellow powder to crystal.
The Uses of Dmt-2'fluoro-da(bz) amidite
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is an adenosine derivative used in the preparation of modified nucleotides to improve metabolic stability and ellicit gene silencing, and in the synthesis of microRNA inhibitors.
Synthesis
3-((Bis(diisopropylamine)phosphanyl)oxy)propanenitrile (6.42 g, 21.3 mmol, 6.77 mL, 1.8 eq) was added to a solution of N-(9-((2R,3R,4R,5R)-5-((bis(4- methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H- purine-6-yl)benzamide (8.0 g, 11.8 mmol, 1.0 eq) in DCM (42 mL) at 0 °C followed by DCI (2.24 g, 18.9 mmol, 1.6 eq). The mixture was warmed to 25 °C and stirred for 3 hours. Two parallel reactions were carried out. The combined remedies were then diluted with DCM (150 mL), the organic layer was washed with sat NaHCO3 solution (200 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated, the crude was purified by column chromatography to give Dmt-2'fluoro-da(bz) amidite (18.0 g, 18.5 mmol, 78.1% yield, 90% purity) as a white solid.
Properties of Dmt-2'fluoro-da(bz) amidite
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
form | Powder |
pka | 7.87±0.43(Predicted) |
color | White to off-white |
Safety information for Dmt-2'fluoro-da(bz) amidite
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Dmt-2'fluoro-da(bz) amidite
InChIKey | ZDIBABNMVQPXHU-JWQXGDSTNA-N |
Dmt-2'fluoro-da(bz) amidite manufacturer
Innovassynth Technologies (I) Ltd.
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