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HomeProduct name listN-azidoacetylmannosamine-tetraacylated

N-azidoacetylmannosamine-tetraacylated

Synonym(s):Ac4ManNAz

  • CAS NO.:361154-30-5
  • Empirical Formula: C16H22N4O10
  • Molecular Weight: 430.37
  • MDL number: MFCD26961126
  • Update Date: 2024-11-18 21:14:07
N-azidoacetylmannosamine-tetraacylated Structural

What is N-azidoacetylmannosamine-tetraacylated?

Description

N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an unnatural azido-containing monosaccharide building block. The azide moiety can be used for modification though chemoselective ligation chemistries including CuAAC, Cu-free click reaction or Staudinger ligation. The acetyl groups increase solubility in many solvents and make handling of this reagent easier.

What are the applications of Application

N-Azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an azide-containing metabolic glycoprotein labeling reagent that can be incorporated into the sialic acid biosynthesis pathway. The azide-modified protein can be detected by reaction with alkynes. For example alkynes labeled with a fluorescent probe or a biotin can be used. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.

The Uses of N-azidoacetylmannosamine-tetraacylated

Tetraacylated N-azidoacetylmannosamine is generally used in click chemistry applications in bioconjugate chemistry.

storage

Store at -20°C

Properties of N-azidoacetylmannosamine-tetraacylated

storage temp.  -20°C
solubility  DMSO:100 mg/mL (232.36 mM; Need ultrasonic
form  powder or crystals
color  White to light yellow

Safety information for N-azidoacetylmannosamine-tetraacylated

Computed Descriptors for N-azidoacetylmannosamine-tetraacylated

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