N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- CAS NO.:181629-93-6
- Empirical Formula: C22H17F4N3O2
- Molecular Weight: 431.38
- MDL number: MFCD00950378
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE?
The Uses of N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
SB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS).
What are the applications of Application
SB 228357 is a SR-2C/SR-2B receptor antagonist
Definition
ChEBI: SB 228357 is an indolyl carboxylic acid.
Biological Activity
5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .
storage
Store at RT
Properties of N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
Boiling point: | 625.4±55.0 °C(Predicted) |
Density | 1.398±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: ~8 mg/mL, soluble |
form | solid |
pka | 9.72±0.70(Predicted) |
color | white |
Safety information for N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
Computed Descriptors for N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
New Products
2,2-diethoxyethanethioamide Tubulysin E (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin F 4-(Benzyloxy)-3-bromophenylacetic Acid 2H-Pyran, 4-ethynyltetrahydro- 3-Aminocyclobutanone hydrochloride 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 1-(1,1-Difluoroethyl)-2-fluorobenzene Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
2-(TRIFLUOROMETHYL)ANISOLE
6-(Trifluoromethyl)indoline
4-AMINO-2-(TRIFLUOROMETHYL)PHENOL
4-Amino-2,5-dimethylphenol
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
alpha,alpha,alpha-Trifluoro-o-cresol
3-Pyridin-3-ylaniline
5-AMINO-2-METHOXYBENZOTRIFLUORIDE
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