N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE

CAS NO.：181629-93-6
Empirical Formula: C22H17F4N3O2
Molecular Weight: 431.38
MDL number: MFCD00950378
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 14:32:37

What is N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE?

The Uses of N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE

SB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS).

What are the applications of Application

SB 228357 is a SR-2C/SR-2B receptor antagonist

Definition

ChEBI: SB 228357 is an indolyl carboxylic acid.

Biological Activity

5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .

storage

Store at RT

Properties of N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE

Boiling point:	625.4±55.0 °C(Predicted)
Density	1.398±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ~8 mg/mL, soluble
form	solid
pka	9.72±0.70(Predicted)
color	white

Safety information for N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE

Computed Descriptors for N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE

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