N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE
- CAS NO.:142128-47-0
- Empirical Formula: C19H39NO2
- Molecular Weight: 313.52
- MDL number: MFCD03412033
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE?
What are the applications of Application
R-Palmitoyl-(1-methyl) Ethanolamide is a synthetic analog of PEA
Definition
ChEBI: R-Palmitoyl-(1-methyl) Ethanolamide is a fatty amide.
Biological Activity
r-palmitoyl-(1-methyl) ethanolamide, a synthetic analog of palmitoyl ethanolamide (pea), incorporates the (r)-methyl group vicinal to the alcohol on the ethanolamine moiety. the analogous modification to arachidonoyl ethanolamide (aea) protects the molecule from hydrolysis by fatty acid amide hydrolase, prolongs duration of action and enhances potency in vivo [1].pea is an endogenous cannabinoid existed in mammalian tissues, such as liver and brain. pea has also been isolated from egg yolk [2, 3]. pea is a compound with documented anti-nociceptive and anti-inflammatory effects. during inflammation, pea is accumulated and exihibits anti-inflammatory effects, including beneficial effects in clinically relevant animal models of inflammatory pain [4].
References
[1] abadji v, lin s, taha g, et al. (r)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability[j]. journal of medicinal chemistry, 1994, 37(12): 1889-1893.
[2] bachur n r, masek k, melmon k l, et al. fatty acid amides of ethanol-amine in mammalian tissues[j]. journal of biological chemistry, 1965, 240: 1019-1024.
[3] ganley o h, graessle o e, robinson h j, et al. anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin[j]. journal of laboratory and clinical medicine, 1958, 51: 709-714.
[4] lambert d m, vandevoorde s, jonsson k o, et al. the palmitoylethanolamide family: a new class of anti-inflammatory agents [j]. current medicinal chemistry, 2002, 9(6): 663-674.
Properties of N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE
storage temp. | Store at -20°C |
solubility | ≤10mg/ml in ethanol;25mg/ml in DMSO;3.3mg/ml in dimethyl formamide |
form | crystalline solid |
Safety information for N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE
Computed Descriptors for N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE
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