N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
Synonym(s):N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride
- CAS NO.:1177141-67-1
- Empirical Formula: C11H14Cl3N3O2S
- Molecular Weight: 358.67176
- MDL number: MFCD00897689
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride?
Chemical properties
Beige Solid
The Uses of N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases
What are the applications of Application
CKI-7 dihydrochloride is an inhibitor of CK1, SGK, p70 S6 Kinase (S6K1) and MSK1.
Biochem/physiol Actions
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.
storage
Store at -20°C
Properties of N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
Melting point: | 187-189°C |
storage temp. | -20°C |
solubility | H2O: >5mg/mL |
form | solid |
color | white to light tan |
Safety information for N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin G Tubulysin F (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin E 6-chloro-4-methylnicotinonitrile S(-)3-Amino tetrahydrofuran 1-Cyclopropyl ethyl amine mandelatesalt quinuclidine-2-carboxylicacid HCl 2-fluoro-5-(Methylsurfonyl)benzoic acid 2-chloro-4-fluoro-5-Iodobenzophenon 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (1-Isopropyl-1H-pyrazol-5-yl)boronic acid Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoateRelated products of tetrahydrofuran
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