N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride

Synonym(s):N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride

CAS NO.：1177141-67-1
Empirical Formula: C11H14Cl3N3O2S
Molecular Weight: 358.67176
MDL number: MFCD00897689
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Structural

What is N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride?

Chemical properties

Beige Solid

The Uses of N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride

Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases

What are the applications of Application

CKI-7 dihydrochloride is an inhibitor of CK1, SGK, p70 S6 Kinase (S6K1) and MSK1.

Biochem/physiol Actions

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.

storage

Store at -20°C

Properties of N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride

Melting point:	187-189°C
storage temp.	-20°C
solubility	H2O: >5mg/mL
form	solid
color	white to light tan

Safety information for N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride

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