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HomeProduct name listMURISTERONE A

MURISTERONE A

MURISTERONE A Structural

What is MURISTERONE A?

Description

Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.

The Uses of MURISTERONE A

Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells.

What are the applications of Application

Muristerone A is a potent inducer of ecdysone-inducible genes

Biological Activity

Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

storage

+4°C

Properties of MURISTERONE A

Boiling point: 707.2±60.0 °C(Predicted)
Density  1.33±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  Soluble in DMSO
form  solid
pka 11.78±0.70(Predicted)
color  white

Safety information for MURISTERONE A

Computed Descriptors for MURISTERONE A

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