MURISTERONE A

CAS NO.：38778-30-2
Empirical Formula: C27H44O8
Molecular Weight: 496.63
MDL number: MFCD00056450
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-20 16:56:14

What is MURISTERONE A?

Description

Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (K_d = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.

The Uses of MURISTERONE A

Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells.

What are the applications of Application

Muristerone A is a potent inducer of ecdysone-inducible genes

Biological Activity

Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

Storage

+4°C

Properties of MURISTERONE A

Boiling point:	707.2±60.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	Soluble in DMSO
form	solid
pka	11.78±0.70(Predicted)
color	white