MMP-9/MMP-13 INHIBITOR I
Synonym(s):MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem;N-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide
- CAS NO.：204140-01-2
- Empirical Formula: C25H25N3O6S
- Molecular Weight: 495.55
- MDL number: MFCD03453559
- Update Date: 2024-07-02 08:55:16
What is MMP-9/MMP-13 INHIBITOR I?
Description
MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.
The Uses of MMP-9/MMP-13 INHIBITOR I
A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13
What are the applications of Application
MMP-9/MMP-13 inhibitor I is a piperazine-based, cell-permeable inhibitor of MMP-9 and MMP-13
What are the applications of Application
MMP-9/MMP-13 Inhibitor II is a potent inhibitor of MMP-9 and MMP-13
Properties of MMP-9/MMP-13 INHIBITOR I
| Density | 1.364±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO or methanol |
| pka | 9.38±0.23(Predicted) |
| form | Solid |
| color | White to off-white |
| Sensitive | Light Sensitive |
Safety information for MMP-9/MMP-13 INHIBITOR I
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for MMP-9/MMP-13 INHIBITOR I
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