ML277
Synonym(s):(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide;(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide;CID-53347902;VU0458298-2, VU0458298-3
- CAS NO.:1401242-74-7
- Empirical Formula: C23H25N3O4S2
- Molecular Weight: 471.59
- MDL number: MFCD28133374
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 16:43:00
What is ML277?
Description
Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-
The Uses of ML277
ML277 has been used as the KCNQ1 activator to treat?cells in lung metastasis?assay.
Biochem/physiol Actions
ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Mutations in the KCNQ1 gene are associated with long QT syndrome (LQTS), a disorder in which the heart muscles take longer than normal to recover after each heart beat and can lead to dangerous arrhythmias such as atrial fibrillation. Activators of KCNQ1 channels could have potential use in treatments of LQTS. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.
storage
Store at -20°C
Properties of ML277
Density | 1.341±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: 5 mg/ml |
form | powder |
pka | 8.37±0.70(Predicted) |
color | white to beige |
Safety information for ML277
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for ML277
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