Mitomycins

Description

Mitomycins are a group of unique chemical structures in which three different carcinostatic functions – aziridine, carbamate, and quinone – are arranged around a pyrroindole nucleus . The first mitomycins were discovered in 1956by Hata in a culture filtrate of Streptomyces caespitosus. These compounds, designated mitomycins A and B, show highly potent antibacterial activity and moderate antitumor activity, but they are quite toxic in mice. In 1958, mitomycin C, an extremely valuable antitumor drug, was isolated from Streptomyces caespitosus , . In 1960, another mitomycin, porfiromycin, was isolated from Streptomyces ardus.

Definition

ChEBI: Mitomycin C is a mitomycin. It has a role as an antineoplastic agent and an alkylating agent. It is a conjugate acid of a mitomycin C(1-).