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HomeProduct name listMiconazole nitrate

Miconazole nitrate

Synonym(s):(±)-Miconazole nitrate salt;1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

  • CAS NO.:22832-87-7
  • Empirical Formula: C18H14Cl4N2O.HNO3
  • Molecular Weight: 479.14
  • MDL number: MFCD00058161
  • EINECS: 245-256-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-21 17:11:28
Miconazole nitrate Structural

What is Miconazole nitrate?

Description

Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14α-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes. Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a MIC value of ≥256 μM against Candida spp.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Miconazole nitrate is an imidazole derivative and a broad spectrum antifungal drug used in the management of fungal outbreak in humans and veterinary animals.

Biochem/physiol Actions

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

The Uses of Miconazole nitrate

Topical miconazole is used to treat tinea corporis(ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection.

Properties of Miconazole nitrate

Melting point: 170-185 C
Density  1.5000 (rough estimate)
refractive index  1.6200 (estimate)
storage temp.  2-8°C
solubility  pyridine: soluble50mg/mL
form  neat
form  Solid
color  white to off-white
optical activity [α]25/D 0°, c = 10 in water
Water Solubility  Slightly soluble in water. Soluble in propylene glycol or pyridine.
Merck  14,6178
CAS DataBase Reference 22832-87-7(CAS DataBase Reference)

Safety information for Miconazole nitrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H317:Sensitisation, Skin
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Miconazole nitrate

InChIKey MCCACAIVAXEFAL-UHFFFAOYSA-N

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