Miconazole nitrate
Synonym(s):(±)-Miconazole nitrate salt;1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
- CAS NO.:22832-87-7
- Empirical Formula: C18H14Cl4N2O.HNO3
- Molecular Weight: 479.14
- MDL number: MFCD00058161
- EINECS: 245-256-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Miconazole nitrate?
Description
Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14α-
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Miconazole nitrate is an imidazole derivative and a broad spectrum antifungal drug used in the management of fungal outbreak in humans and veterinary animals.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.
The Uses of Miconazole nitrate
Topical miconazole is used to treat tinea corporis(ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection.
Properties of Miconazole nitrate
Melting point: | 170-185 C |
Density | 1.5000 (rough estimate) |
refractive index | 1.6200 (estimate) |
storage temp. | 2-8°C |
solubility | pyridine: soluble50mg/mL |
form | neat |
form | Solid |
color | white to off-white |
optical activity | [α]25/D 0°, c = 10 in water |
Water Solubility | Slightly soluble in water. Soluble in propylene glycol or pyridine. |
Merck | 14,6178 |
CAS DataBase Reference | 22832-87-7(CAS DataBase Reference) |
Safety information for Miconazole nitrate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Miconazole nitrate
InChIKey | MCCACAIVAXEFAL-UHFFFAOYSA-N |
Abamectin manufacturer
Rasino Drugs Pvt Ltd
FDC Limited
Kenoor Organics Private Limited
Om Pharmaceutical Industries
Neugen Labs
Afton Pharma
Humble Healthcare Limited
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