Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listMiconazole nitrate

Miconazole nitrate

Synonym(s):(±)-Miconazole nitrate salt;1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

  • CAS NO.:22832-87-7
  • Empirical Formula: C18H14Cl4N2O.HNO3
  • Molecular Weight: 479.14
  • MDL number: MFCD00058161
  • EINECS: 245-256-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
Miconazole nitrate Structural

What is Miconazole nitrate?

Description

Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14α-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes. Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a MIC value of ≥256 μM against Candida spp.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Miconazole nitrate is an imidazole derivative and a broad spectrum antifungal drug used in the management of fungal outbreak in humans and veterinary animals.

Biochem/physiol Actions

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

The Uses of Miconazole nitrate

Topical miconazole is used to treat tinea corporis(ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection.

Properties of Miconazole nitrate

Melting point: 170-185 C
Density  1.5000 (rough estimate)
refractive index  1.6200 (estimate)
storage temp.  2-8°C
solubility  pyridine: soluble50mg/mL
form  neat
form  Solid
color  white to off-white
optical activity [α]25/D 0°, c = 10 in water
Water Solubility  Slightly soluble in water. Soluble in propylene glycol or pyridine.
Merck  14,6178
CAS DataBase Reference 22832-87-7(CAS DataBase Reference)

Safety information for Miconazole nitrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H317:Sensitisation, Skin
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Miconazole nitrate

InChIKey MCCACAIVAXEFAL-UHFFFAOYSA-N

Abamectin manufacturer

Rasino Drugs Pvt Ltd

1Y
Phone:+91-9372023582
Whatsapp: +91 9821407921
product: MICONAZOLE NITRATE 98%
Inquiry

FDC Limited

1Y
Phone:+912226782653
Whatsapp: +91- XXXXXXXXXX
product: Miconazole nitrate 22832-87-7 98%
Inquiry

Kenoor Organics Private Limited

1Y
Phone:+91-7227026012
Whatsapp: +91 7227026012
product: 22832-87-7 Miconazole nitrate 98%
Inquiry

Om Pharmaceutical Industries

1Y
Phone:+91-9822376539
Whatsapp: +91-9822376539
product: 22832-87-7 99%
Inquiry

Gufic Group

1Y
Phone:+91-2267261000
product: Miconazole nitrate 98%
Inquiry

Neugen Labs

1Y
Phone:+91-8133254502
Whatsapp: +91-8133254502
product: Miconazole nitrate 22832-87-7 98%
Inquiry

Afton Pharma

1Y
Phone:+91-9712000202
Whatsapp: +91-9712000202
product: 22832-87-7 Miconazole nitrate 98%
Inquiry

Sharon Bio Medicine Ltd

1Y
Phone:+91-9821911142
Whatsapp: +91 9821911142
product: 22832-87-7 99%
Inquiry

Humble Healthcare Limited

1Y
Phone:+91-8006400378
Whatsapp: +91 8006400378
product: Miconazole nitrate 99%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.