METHYL 3-METHOXY-4-METHYLBENZOATE

CAS NO.：3556-83-0
Empirical Formula: C10H12O3
Molecular Weight: 180.2
MDL number: MFCD00082710
EINECS: 609-142-3
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is METHYL 3-METHOXY-4-METHYLBENZOATE?

Chemical properties

White low melting solid

The Uses of METHYL 3-METHOXY-4-METHYLBENZOATE

Methyl 3-Methoxy-4-methylbenzoate has been used as a reactant in the preparation of an antimalaria drug that consists of the 4-aminoquinoline pharmacophore of chloroquine with clotrimazole-based antimalarials.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 1771, 1990 DOI: 10.1021/jm00168a036

General Description

Methyl 3-methoxy-4-methylbenzoate can be prepared by reacting diazomethane with 3-methoxy-4-methylbenzoic acid in ether.

Properties of METHYL 3-METHOXY-4-METHYLBENZOATE

Melting point:	50-54 °C (lit.)
Boiling point:	119-120°C 1mm
Density	1.075±0.06 g/cm3(Predicted)
refractive index	1.5295
Flash point:	>230 °F
form	powder to crystal
color	White to Almost white
BRN	1948339
CAS DataBase Reference	3556-83-0(CAS DataBase Reference)

Safety information for METHYL 3-METHOXY-4-METHYLBENZOATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.