methyl 2-fluoro-3-nitrobenzoate
- CAS NO.:946126-94-9
- Empirical Formula: C8H6FNO4
- Molecular Weight: 199.14
- MDL number: MFCD10566813
- EINECS: 689-721-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is methyl 2-fluoro-3-nitrobenzoate?
The Uses of methyl 2-fluoro-3-nitrobenzoate
Methyl 2-fluoro-3-nitrobenzoate can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Synthesis
A solution of 2-fluoro-3-nitrobenzoic acid (5 g, 27.0 mmol) in MeOH (50 mL) was treated with concentrated H2SO4 (1.4 mL, 27.0 mmol) and the resulting reaction was stirred at 50 °C for 16 h. The solvent was removed under reduced pressure and the residue was diluted with EtO Ac. The organic solution was washed with saturated aqueous NaHCO3 solution until the water phase reached neutral pH. The two phases were separated. Organics were washed with water, brine and dried (Na2SO4). The solution was filtered and concentrated to give crude methyl 2-fluoro-3-nitrobenzoate which was used as is in the next step. (5.1 g, 25.2 mmol, 93 %) as a pale yellow solid.
Properties of methyl 2-fluoro-3-nitrobenzoate
Melting point: | 77- 80° C |
Boiling point: | 310.8±27.0 °C(Predicted) |
Density | 1.388±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
color | Off-White to Pale Yellow |
Safety information for methyl 2-fluoro-3-nitrobenzoate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for methyl 2-fluoro-3-nitrobenzoate
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AATAMI Molecular Research Laboratories Pvt Ltd (AMRL)
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