Methyl 2-bromomethyl-3-nitrobenzoate

CAS NO.：98475-07-1
Empirical Formula: C9H8BrNO4
Molecular Weight: 274.07
MDL number: MFCD04114315
EINECS: 619-354-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-16 18:36:03

What is Methyl 2-bromomethyl-3-nitrobenzoate?

Description

Methyl 2-bromomethyl-3-nitrobenzoate is a white or light yellow solid under normal temperature and pressure. It is insoluble in water but soluble in alcoholic organic solvents.

Chemical properties

Pale Yellow Solid

The Uses of Methyl 2-bromomethyl-3-nitrobenzoate

Methyl 2-bromomethyl-3-nitrobenzoate is an organic ester derivative that can be used as an organic synthesis intermediate and a raw material for pharmaceutical chemical synthesis. It is a crucial synthesis intermediate for the drug molecule lenalidomide. Lenalidomide is an antineoplastic drug.

Structure

The ester group and benzyl bromide unit in the Methyl 2-bromomethyl-3-nitrobenzoate structure are easily convertible functional groups. Its structure contains a strong electron-attracting nitro group and an easily leaving bromine atom. The nitro group is a strong electron-withdrawing group that can increase the reactivity of molecules through conjugation effects and electron attraction. Due to these properties, it has wide applications in organic synthesis transformations.

Properties of Methyl 2-bromomethyl-3-nitrobenzoate

Melting point:	72-74°
Boiling point:	370.9±32.0 °C(Predicted)
Density	1.624±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Methanol
form	Solid
color	White to Light yellow
InChI	InChI=1S/C9H8BrNO4/c1-15-9(12)6-3-2-4-8(11(13)14)7(6)5-10/h2-4H,5H2,1H3

Safety information for Methyl 2-bromomethyl-3-nitrobenzoate

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.