Methoxypolyethylene glycol amine

Description

m-PEG15-amine is a PEG linker containing an amino group and 15 PEG units. It is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.

The Uses of Methoxypolyethylene glycol amine

MPEG-NH2 is a reactant in synthesis of pH-sensitive polymeric micelles for intracellular drug delivery.

The Uses of Methoxypolyethylene glycol amine

PEG functionalized with amine for ligation and coupling reactions.

The Uses of Methoxypolyethylene glycol amine

Methoxypolyethylene glycol amine is generally used for the chemical modification of biologically active compounds and therapeutic agents. It has been used to increase the aqueous solubility of long-wavelength voltage-sensitive dyes and to prepare the PEG-coated fluorescent beads in studying large-scale rotational cytoplasmic flow.

What are the applications of Application

Methoxypolyethylene glycol amine is used in the reduction of immunogenicity and increasing serum half life.Methoxypolyethylene glycol amine can:
Form dendritic micelles to enhance the solubility of hydrophobic compounds.
Conjugate with an anticancer drug methotrexate (MTX) to form MTX-PEG with potential application as drug carriers.
Couple with polyethylenimine (PEI) to form graft copolymers which can be used as nonviral gene vectors.
PEG functionalized with amine for ligation and coupling reactions.

What are the applications of Application

Methoxypolyethylene glycol amine is an oligomer used to prepare PEG-ylated conjugates having the advantage of reduced immunogenicity and increased serum half life