methoctramine tetrahydrochloride hemihydrate
Synonym(s):Methoctramine tetrahydrochloride hydrate;N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate
- CAS NO.：104807-46-7
- Empirical Formula: 2C36H62N4O2.4ClH.H2O
- Molecular Weight: 1329.68
- MDL number: MFCD11045942
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is methoctramine tetrahydrochloride hemihydrate?
The Uses of methoctramine tetrahydrochloride hemihydrate
Methoctramine is a muscarinic M2 receptor antagonist.
The Uses of methoctramine tetrahydrochloride hemihydrate
Methoctramine hydrate has been used:
- As a muscarinic receptor 2 antogonist.
- As a test molecule to check its effect on premature osteogenic differentiation of HGPS (Hutchinson-Gilford progeria syndrome) iPS (induced pluripotent)-derived mesenchymal stem cells.
What are the applications of Application
Methoctramine is a mAChR M2 (muscarinic M2 receptor) antagonist
Definition
ChEBI: A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.
General Description
Methoctramine (N, N′-bis [6-[[(2-methoxyphenyl)-methyl] hexyl]-1, 8-octane] diamine) is a derivative of polymethylene tetramine.
Biochem/physiol Actions
Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification.
Properties of methoctramine tetrahydrochloride hemihydrate
| storage temp. | 2-8°C |
| solubility | H2O: >20mg/mL |
| form | solid |
| color | white |
Safety information for methoctramine tetrahydrochloride hemihydrate
Computed Descriptors for methoctramine tetrahydrochloride hemihydrate
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