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HomeProduct name list(+)METHAMPHETAMINE HYDROCHLORIDE

(+)METHAMPHETAMINE HYDROCHLORIDE

  • CAS NO.:51-57-0
  • Empirical Formula: C10H16ClN
  • Molecular Weight: 185.69
  • MDL number: MFCD00056130
  • EINECS: 200-106-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2022-12-21 16:56:50
(+)METHAMPHETAMINE HYDROCHLORIDE Structural

What is (+)METHAMPHETAMINE HYDROCHLORIDE?

Description

(+)-Methamphetamine (Item No. 13997) is an analytical reference material categorized as an amphetamine. It is the more physiologically active isomer of (±)-methamphetamine and is both neurotoxic and frequently abused. Methamphetamine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Chemical properties

Off-White Solid

Originator

Desoxyn ,Abbott Laboratories

The Uses of (+)METHAMPHETAMINE HYDROCHLORIDE

A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity. Controlled substance (stimulant).

Definition

ChEBI: A hydrochloride having methamphetamine as the base component.

Manufacturing Process

2 Methods of prepearing of methamphetamine:
1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.
2. Methamphetamine was obtained by the methylation of phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was treated by eqimolar quantity of hydrochloric acid.

Therapeutic Function

Sympathomimetic, Central stimulant

General Description

Methamphetamine, (+)-1-phenyl-2-methylaminopropanehydrochloride desoxyephedrine hydrochloride (Desoxyn), isthe N-methyl analog of dextroamphetamine. It has moremarked central and less peripheral action than dextroamphetamine.It has a very high abuse potential, and by the intravenousroute, its salts are known as “speed.” The overallabuse problem presented by the drug is a national disaster.Medicinally acceptable uses of methamphetamine are analogousto those of dextroamphetamine.

Biochem/physiol Actions

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits toxic fumes of NOx and HCl. See also BENZEDRINE and various amphetamines.

Properties of (+)METHAMPHETAMINE HYDROCHLORIDE

Melting point: 166-168?C
alpha  D25 +14 to +20°
Flash point: 9°C
storage temp.  Controlled Substance, -20°C Freezer
EPA Substance Registry System Methamphetamine hydrochloride (51-57-0)

Safety information for (+)METHAMPHETAMINE HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for (+)METHAMPHETAMINE HYDROCHLORIDE

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