Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listMELPERONE

MELPERONE

  • CAS NO.:3575-80-2
  • Empirical Formula: C16H22FNO
  • Molecular Weight: 263.35
  • MDL number: MFCD00867737
  • EINECS: 609-173-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
MELPERONE Structural

What is MELPERONE?

Originator

Eunerpan,Nordmark,W. Germany,1965

Definition

ChEBI: 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone is an aromatic ketone.

Manufacturing Process

A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.
Yield 22.0 g (73% of theory). MP 209°C to 211°C.

Therapeutic Function

Neuroleptic

Properties of MELPERONE

Melting point: 78.0 to 82.0 °C
Boiling point: bp0.1 120-125°
Density  1.046±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO: 41.67 mg/mL (158.23 mM)
pka 9.34±0.10(Predicted)
form  powder to crystal
color  White to Light yellow to Light orange
Merck  14,5827

Safety information for MELPERONE

Computed Descriptors for MELPERONE

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.