MELPERONE
- CAS NO.：3575-80-2
- Empirical Formula: C16H22FNO
- Molecular Weight: 263.35
- MDL number: MFCD00867737
- EINECS: 609-173-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-19 18:29:52
What is MELPERONE?
Originator
Eunerpan,Nordmark,W. Germany,1965
Definition
ChEBI: 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone is an aromatic ketone.
Manufacturing Process
A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.
Yield 22.0 g (73% of theory). MP 209°C to 211°C.
Therapeutic Function
Neuroleptic
Properties of MELPERONE
| Melting point: | 78.0 to 82.0 °C |
| Boiling point: | bp0.1 120-125° |
| Density | 1.046±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 41.67 mg/mL (158.23 mM) |
| pka | 9.34±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Merck | 14,5827 |
Safety information for MELPERONE
Computed Descriptors for MELPERONE
New Products
Tubulysin A Tubulysin F 2,2-diethoxyethanethioamide Tubulysin M 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 1-(1,1-Difluoroethyl)-2-fluorobenzene 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2H-Pyran, 4-ethynyltetrahydro- 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
![SPIPERONE, [BENZENE RING-3H]](https://img.chemicalbook.in/CAS/GIF/80154-50-3.gif)
![N-METHYL-8-[4-(4-FLUOROPHENYL)-4-OXOBUTYL]-1-PHENYL-1,3,8-TRIAZASPIRO-[4.5]DECAN-4-ONE HYDROCHLORIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure1/GIF/CB1219384.gif)
![METHYLSPIPERONE, [N-METHYL-3H]](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB3167067.gif)
You may like
-
Melperone CAS 3575-80-2View Details
3575-80-2 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8