MEGA-10

Synonym(s):N-(D-Glucityl)-N-methyldecanamide;N-Decanoyl-N-methyl-D-glucamine;MEGA-10;N-decanoyl-N-methylglucamine

CAS NO.：85261-20-7
Empirical Formula: C17H35NO6
Molecular Weight: 349.46
MDL number: MFCD21607087
EINECS: 617-695-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is MEGA-10?

The Uses of MEGA-10

Non-ionic detergent for solubilizing membrane proteins

What are the applications of Application

N-Decanoyl-N-methylglucamine is a water-soluble, nondenaturing detergent useful for membrane research

Purification Methods

Possible impurities are decanoic acid and N-methylglycamine. The former is removed by grinding the solid with Et2O and then with pet ether and drying over P2O5. It is twice recrystallised from MeOH/Et2O by dissolving in the minimum volume of MeOH, adding Et2O and drying in a vacuum. To remove the glycamine, the solid (800mg) is dissolved in hot H2O (10mL) and set aside. Mega-10 crystallises as colourless needles. These are filtered off and dried in a vacuum to constant weight. It is a good non-ionic non-hygroscopic detergent with a critical micelle concentration (CMC) of 7.4mM (0.26%) in 0.1M Tris-HCl pH 7.4 at 25o. [Hildreth Biochem J 207 363 1982.]

Properties of MEGA-10

Melting point:	91-93 °C
Boiling point:	595.8±50.0 °C(Predicted)
Density	1.155±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: 10 mg/mL at 20 °C, clear, colorless
pka	13.44±0.20(Predicted)
form	Solid
color	White to Off-White
Water Solubility	Soluble in methanol at 50mg/ml. Also soluble in water at 10mg/ml 20 °C
BRN	6974359
EPA Substance Registry System	N-Oxodecyl meglumine (85261-20-7)

Safety information for MEGA-10

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.