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HomeProduct name listMEGA-10

MEGA-10

Synonym(s):N-(D-Glucityl)-N-methyldecanamide;N-Decanoyl-N-methyl-D-glucamine;MEGA-10;N-decanoyl-N-methylglucamine

  • CAS NO.:85261-20-7
  • Empirical Formula: C17H35NO6
  • Molecular Weight: 349.46
  • MDL number: MFCD21607087
  • EINECS: 617-695-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:07:02
MEGA-10 Structural

What is MEGA-10?

The Uses of MEGA-10

Non-ionic detergent for solubilizing membrane proteins

What are the applications of Application

N-Decanoyl-N-methylglucamine is a water-soluble, nondenaturing detergent useful for membrane research

Purification Methods

Possible impurities are decanoic acid and N-methylglycamine. The former is removed by grinding the solid with Et2O and then with pet ether and drying over P2O5. It is twice recrystallised from MeOH/Et2O by dissolving in the minimum volume of MeOH, adding Et2O and drying in a vacuum. To remove the glycamine, the solid (800mg) is dissolved in hot H2O (10mL) and set aside. Mega-10 crystallises as colourless needles. These are filtered off and dried in a vacuum to constant weight. It is a good non-ionic non-hygroscopic detergent with a critical micelle concentration (CMC) of 7.4mM (0.26%) in 0.1M Tris-HCl pH 7.4 at 25o. [Hildreth Biochem J 207 363 1982.]

Properties of MEGA-10

Melting point: 91-93 °C
Boiling point: 595.8±50.0 °C(Predicted)
Density  1.155±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  H2O: 10 mg/mL at 20 °C, clear, colorless
pka 13.44±0.20(Predicted)
form  Solid
color  White to Off-White
Water Solubility  Soluble in methanol at 50mg/ml. Also soluble in water at 10mg/ml 20 °C
BRN  6974359
EPA Substance Registry System N-Oxodecyl meglumine (85261-20-7)

Safety information for MEGA-10

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for MEGA-10

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