Mal-PEG5-CH2CH2Mal
- CAS NO.：113387-03-4
- Empirical Formula: C20H28N2O9
- Molecular Weight: 440.44
- MDL number: MFCD31706204
- Update Date: 2024-03-27 14:23:05
What is Mal-PEG5-CH2CH2Mal?
Biological Activity
Mal-PEG5-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Safety information for Mal-PEG5-CH2CH2Mal
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