Mal-PEG1-NHS ester
- CAS NO.：1807518-72-4
- Empirical Formula: C13H14N2O7
- Molecular Weight: 310.26
- MDL number: MFCD26127783
- Update Date: 2024-11-19 20:33:22
What is Mal-PEG1-NHS ester?
Description
Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Biological Activity
Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of Mal-PEG1-NHS ester
| Boiling point: | 488.4±55.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| solubility | Soluble in DCM |
| pka | -2.35±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for Mal-PEG1-NHS ester
Computed Descriptors for Mal-PEG1-NHS ester
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