Madrasin

Synonym(s):2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-3H-pyrimidin-4-one;2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone (9CI);4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-(9CI);4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-;RNAsplicing inhibitor

CAS NO.：374913-63-0
Empirical Formula: C16H17N5O2
Molecular Weight: 311.34
MDL number: MFCD02233199
Update Date: 2024-11-14 14:09:35

What is Madrasin?

The Uses of Madrasin

Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.

Definition

ChEBI: 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-one is a member of quinazolines.

Biochem/physiol Actions

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.

Properties of Madrasin

storage temp.	2-8°C
solubility	DMSO:1.5(Max Conc. mg/mL);4.82(Max Conc. mM)
form	powder
color	white to dark brown

Safety information for Madrasin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral

Computed Descriptors for Madrasin

New Products

4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-(dimethylamino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one Iminostilbene 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Diclofenac Sodium SODIUM VALPROATE Racecadotril XANTHAN GUM 5-Fluoro-2-iodo-3-methylphenol 4-(Cyanomethyl)-1-piperidineacetamide 6-Bromo-2-iodo-4-methyl-3-pyridinamine 5-Amino-3-bromo-2-chlorobenzeneacetic acid