LFM-A13
Synonym(s):α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide;α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide, BTK Inhibitor I, Bruton′s Tyrosine Kinase Inhibitor I;(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide;LFM-A13 - CAS 62004-35-7 - Calbiochem
- CAS NO.：62004-35-7
- Empirical Formula: C11H8Br2N2O2
- Molecular Weight: 360
- MDL number: MFCD02179204
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is LFM-A13?
The Uses of LFM-A13
LFM-A13 is a novel anti-leukemic agent targeting Bruton''s tyrosine kinase (BTK). LFM-A13 is a BTK inhibitor.
What are the applications of Application
LFM-A13 is a potent and selective inhibitor of Btk
Biological Activity
Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC 50 value of 2.5 μ M and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μ M.
storage
Store at RT
Properties of LFM-A13
| storage temp. | −20°C |
| solubility | DMSO: 15 mg/mL |
| form | powder |
| color | white |
Safety information for LFM-A13
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to..… |
Computed Descriptors for LFM-A13
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