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HomeProduct name listLEUROSINE

LEUROSINE

LEUROSINE Structural

What is LEUROSINE?

Description

Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).

The Uses of LEUROSINE

Vinleurosine is an antitumor compound derived from Vinca Rosea.

The Uses of LEUROSINE

Antineoplastic.

Definition

ChEBI: Leurosine is a vinca alkaloid.

References

Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)

Properties of LEUROSINE

Melting point: 202-205℃
Density  1.39
pka 11.36±0.60(Predicted)

Safety information for LEUROSINE

Computed Descriptors for LEUROSINE

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