laudanosine
- CAS NO.：2688-77-9
- Empirical Formula: C21H27NO4
- Molecular Weight: 357.44
- MDL number: MFCD27978049
- EINECS: 220-253-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is laudanosine ?
The Uses of laudanosine
Laudanosine is a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.
Definition
ChEBI: Laudanosine is a member of isoquinolines.
Purification Methods
Crystallise these from EtOH. The (±)-picrate crystallises from EtOH with m 177-178o. The (-)-isomer has m 83-85o and
Properties of laudanosine
| Melting point: | 89° |
| Boiling point: | 490.07°C (rough estimate) |
| alpha | D16 +106° (c = 1.6 in 97% alc); D16 +130° (chloroform); D22 +52.2 ±1.3° (chloroform); D20 +82.5° (ethanol) |
| Density | 1.1729 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated) |
| form | White to Pale Beige |
| pka | 7.80±0.40(Predicted) |
Safety information for laudanosine
Computed Descriptors for laudanosine
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION AMOXICILLIN (AMOXYCILLIN) TRIHYDRATE ACICLOVIR AMLODIPINE SODIUM METHYL PARABEN Methylcobalamin (vitamin B12) SODIUM VALPROATE 5-Fluoro-2-iodo-3-methylaniline Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 3-Bromo-2-hydroxybenzeneacetic acid 5-Iodo-3-methyl-2-nitropyridine 1-(3-Chloro-2-hydroxyphenyl)-2-propanoneRelated products of tetrahydrofuran
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