Lanthanum Carbonate
- CAS NO.:587-26-8
- Empirical Formula: C3La2O9
- Molecular Weight: 457.84
- MDL number: MFCD00011069
- EINECS: 209-599-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Lanthanum Carbonate?
Absorption
Bioavailability very low (<0.002%) following single or multiple dose oral administration.
Toxicity
The symptoms associated with overdose are adverse reactions such as headache, nausea and vomiting. Lanthanum carbonate was not acutely toxic in animals by the oral route. No deaths and no adverse effects occurred in mice, rats or dogs after single oral doses of 2000 mg/kg.
The Uses of Lanthanum Carbonate
Treatment of hyperphosphatae mia in patients with end stage renal disease.
Background
Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name Fosrenol by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led to severe choking. It is prescribed for treating high phosphate levels, mainly found in patients with chronic kidney disease. Lanthanum should be taken with meals and binds to phosphate in the diet, preventing phosphate absorption in the intestine.
Indications
Used to reduce serum phosphate in patients with end stage renal disease (ESRD).
brand name
Fosrenol (Shire).
Flammability and Explosibility
Not classified
Pharmacokinetics
In vitro studies have shown that lanthanum binds phosphate in the physiologically relevant pH range of 3 to 7. In simulated gastric fluid, lanthanum binds approximately 97% of the available phosphate at pH 3-5 and 67% at pH 7, when lanthanum is present in a two-fold molar excess to phosphate. Bile acids have not been shown to affect the phosphate binding affinity of lanthanum. In order to bind dietary phosphate, lanthanum carbonate must be administered with or immediately after meals.
Metabolism
Lanthanum is not metabolized.
Properties of Lanthanum Carbonate
Density | 3.48[at 20℃] |
Water Solubility | 1.24mg/L at 20℃ |
CAS DataBase Reference | 587-26-8 |
EPA Substance Registry System | Carbonic acid, lanthanum(3+) salt (3:2) (587-26-8) |
Safety information for Lanthanum Carbonate
Computed Descriptors for Lanthanum Carbonate
Abamectin manufacturer
Sam Fine O Chem Limited
Afton Pharma
Solara Active Pharma Sciences Ltd
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