L371,257
- CAS NO.：162042-44-6
- Empirical Formula: C28H33N3O6
- Molecular Weight: 507.58
- MDL number: MFCD00944944
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:39
What is L371,257?
The Uses of L371,257
L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.
What are the applications of Application
L-371,257 is a potent oxytocin receptor inhibitor
Biological Activity
Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.
storage
Store at RT
Properties of L371,257
| Boiling point: | 728.9±60.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 10 mM in DMSO with gentle warming |
| form | Powder |
| pka | 0.73±0.20(Predicted) |
| color | White to off-white |
Safety information for L371,257
Computed Descriptors for L371,257
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